Magnetic Resonance Spectroscopic Imaging Determines Therapeutic Immunization Efficacy in an Animal Model of Parkinson’s Disease
نویسندگان
چکیده
Michael D. Boska,1,2 Travis B. Lewis,1 Christopher J. Destache,1,4 Eric J. Benner,1 Jay A. Nelson,1,2 Mariano Uberti,1,2 R. Lee Mosley,1,3* and Howard E. Gendelman1,3* 1Center for Neurovirology and Neurodegenerative Disorders, Departments of 2Radiology and 3Pharmacology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5215, and 4Department of Pharmacy Practice, College of Pharmacy, Creighton University Medical Center, Omaha, Nebraska 68131
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Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization efficacy in an animal model of Parkinson's disease.
Nigrostriatal degeneration, the pathological hallmark of Parkinson's disease (PD), is mirrored by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication. MPTP-treated animals show the common behavioral, motor, and pathological features of human disease. We demonstrated previously that adoptive transfer of Copaxone (Cop-1) immune cells protected the nigrostriatal dopaminergic pathway i...
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